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MLB Parlay Picks for June 6: Phillies on the Moneyline, Cubs on the Run Line 38s3u

Yankees to Win vs. Red Sox 11456o

SportsHandle StaffSportsHandle Staff
June 6, 2025
in Sports

Wendell Cruz-Imagn Images. UCreate MLB parlay betslip with our picks: Phillies and Yankees on the Moneyline z2m4k

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Yet another weekend and yet another chance to get our MLB parlays picks. We start things off with the Phillies vs. Pirates National League matchup, with the visiting team trying to take advantage of Pittsburgh’s bad form to get a win. The Astros, top AL West, go up against the Cleveland Guardians, with Houston trying to keep the momentum going.

But the most interesting game of the weekend is the rivalry game between the Boston Red Sox and the New York Yankees. So let’s see where things could be heading in these matchups.

Game Date Tip Alternative Bet
Philadelphia Phillies vs. Pittsburgh Pirates Friday, June 6 Philadelphia Phillies on the Moneyline Under 9 Runs
Texas Rangers vs. Washington Nationals Friday, June 6 Under 9.5 Runs Nationals on the Run Line
Boston Red Sox vs. New York Yankees Friday, June 6 Yankees on the Moneyline Over 9 Runs
Houston Astros vs. Cleveland Guardians Friday, June 6 Astros on the Moneyline Over 8.5 Runs
Chicago Cubs vs. Detroit Tigers Friday, June 6 Cubs on the Run Line Under 7 Runs

*Sports betting carries inherent risks, and outcomes can be unpredictable. The recommendations offered here are based on current data and analysis but should not be viewed as guarantees of success.

Philadelphia Phillies vs. Pittsburgh Pirates – Philadelphia Phillies on the Moneyline 6v351d

We start things off when the Philadelphia Phillies visit the Pittsburgh Pirates at PNC Park on Friday for the start of a three-game series. The Phillies (37-25) hold a solid second place in the NL East, while the Pirates (23-40) struggle near the bottom of the NL Central. Philadelphia is favored at -140 on the moneyline, with Pittsburgh as the +119 underdog. The total runs line is set at 9.

Pitching matchups feature Phillies’ Joe Ross, who has a 4.34 ERA this season, against Pirates’ Bailey Falter, who has been effective with a 3.14 ERA. The Phillies have been scoring more runs recently, averaging 4.57 runs over their last 27 games compared to the Pirates’ 3.16 runs in their last 25. However, the Phillies have been outscored in recent games and have a higher team ERA, indicating some vulnerability.

We would say taking the Philadelphia Phillies on the moneyline. They have won all three matchups against the Pirates this season and have a stronger overall roster and offensive output. But you can also consider the under 9 runs total. Both teams have hit into numerous double plays, and recent games between them have often stayed under the total runs line.

Texas Rangers vs. Washington Nationals – Under 9.5 Runs 54401w

The Texas Rangers visit Nationals Park to face the Washington Nationals in the first game of their three-game series. The Rangers, with a 29-34 record, are slight favorites with moneyline odds around -125, while the Nationals stand close behind at +105 as underdogs.

Patrick Corbin will start for Texas, facing off against Washington’s Mike Soroka. Both teams have struggled offensively lately, with the Rangers averaging about 3.3 runs per game and the Nationals around 3.7 in their recent five games. Pitching performances have been mixed, but neither starter is likely to dominate completely.

From a betting perspective, the total runs line is set at 9.5, and recent trends suggest the under is a solid choice. The combined scoring in recent matchups has been low, with the under hitting in most of the last several games between these teams. Both teams have shown a tendency to keep games under this total, making the under 9.5 runs a main betting tip.

An alternative betting option is to back the Nationals with the +1.5 run line. Despite being underdogs, Washington has a decent chance to cover the spread, especially at home, where they have been competitive.

Boston Red Sox vs. New York Yankees – Yankees on the Moneyline 381y5b

The Boston Red Sox visit Yankee Stadium to face the New York Yankees in a key AL East matchup. The Yankees, currently leading the division with a 38-23 record, are favored at -175 on the moneyline, while the Red Sox stand at +146 as underdogs with a 30-34 record.

New York will start right-hander Will Warren (3-3), who has nearly 70 strikeouts this season and has been strong at home. Boston counters with Walker Buehler (4-3, 4.44 ERA), making his first career start against the Yankees. The Yankees boast a powerful lineup led by Aaron Judge, who is hitting .392 with 21 home runs and 50 RBIs, making them a formidable opponent.

The main tip would be to back the Yankees on the moneyline. New York has been successful as favorites this season, winning 12 of 15 games when favored at -175 or more, and Warren’s pitching and the team’s home run power give them an edge. The alternative tip is to take the over on the total runs, set at 9, as both teams have shown scoring ability and Buehler has allowed multiple runs in recent starts, suggesting a higher-scoring game.

Houston Astros vs. Cleveland Guardians – Astros on the Moneyline 1m7134

The Houston Astros visit the Cleveland Guardians at Progressive Field for the first game of their three-game MLB series. The Guardians are slight favorites with a moneyline of -112, while the Astros are underdogs at -107. The run line favors Cleveland at -1.5, and the total runs line is set at 8.5.

Houston has shown resilience as underdogs this season, winning 55% of such games, while Cleveland has a strong record of 14-7 when favored by -112 or more. The Guardians have a slight edge in win probability at 51%, but the Astros remain competitive with a 49% chance.

For betting tips, the main recommendation is to back the Astros on the moneyline. Their ability to win as underdogs makes this a value bet given the close odds. Alternatively, consider betting on the game to go over 8.5 runs, as both teams have offensive potential and the projected score suggests a combined total around 9 runs.

Chicago Cubs vs. Detroit Tigers – Cubs on the Run Line 512i1b

The Chicago Cubs visit the Detroit Tigers at Comerica Park on Friday. The Tigers are favored at around -205 on the moneyline, while the Cubs are underdogs at about +170. The total runs line is set near 7 runs. Detroit will start Tarik Skubal (5-2, 2.26 ERA), a solid pitcher who has been effective this season. The Cubs counter with Ben Brown (3-3, 5.72 ERA), who has struggled more but has had some recent success in relief outings.

The Tigers have a strong home record (21-8) and lead the AL Central, while the Cubs lead the NL Central and have a good road record (19-12). Detroit’s offense has cooled a bit lately, scoring two or fewer runs in four of their last six games, but they remain a threat. Chicago’s offense is productive, averaging 5.7 runs per game, led by hitters like Pete Crow-Armstrong and Seiya Suzuki.

Take the Cubs +1.5 runs on the run line. The Cubs have been competitive as underdogs and should keep this game close, especially with Detroit’s offense somewhat inconsistent recently and Brown pitching better in relief.

Alternatively, ret the total runs under 7. Both teams have solid pitching matchups, and recent games suggest a lower-scoring affair is likely.

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SportsHandle Staff

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Sports Handle is home for information on the legal U.S. sports wagering industry — legislation, business, and policy. The team is comprised of veteran journalists who deliver original and investigative reporting, opinion, and analysis of sports betting legislation and regulation at the state and federal levels, plus coverage of the sports betting business landscape. For the latest news, follow along on Twitter at @sports_handle.

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